NFL Week 6 Expert Tips & Predictions

The NFL continues with Week 6 action, and we have NFL expert betting picks and predictions for every game of the year.

It starts with the Eagles vs. Giants on Friday, and the featured games this week include Broncos vs. Jets, Seahawks vs. Jaguars, and Lions vs. Chiefs.

NFL Week 6 Tips

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Friday 10/10/25

11:15am Eagles vs. Giants @ MetLife Stadium

Betting Tip: Eagles –7.5 @ $1.90

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The Eagles come off a shock loss to Denver, but getting to play the Giants should ease their pain.

The Giants didn’t show much last week, and although they’re playing at home, we can’t trust this team to keep Saquon Barkley and Jalen Hurts out of the end zone.

Take the visitors to win and cover the spread.

Eagles by 10

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Monday 13/10/25

12:30am Broncos vs. Jets @ Tottenham Hotspur Stadium

Betting Tip: Broncos –7.5 @ $1.90

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The Broncos looked good when coming from 17-3 down against the Eagles and travelling to London shouldn’t worry them against the Jets.

New York is playing terribly, and the Jets are in line for having the worst record in the NFL this year. They have no attack, and their inexperienced quarterback is suffering.

Bo Nix is playing well for Denver, so back them to win.

Broncos by 10

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4:00am Cardinals vs. Colts @ Lucas Oil Stadium

Betting Tip: Colts –6.5 @ $1.90

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We like what the Colts have done in 2025, including three wins at home. They play another home game against the Cardinals, and this looks like an ideal time to post a 5-1 record.

The Cardinals are 2-3 after showing inconsistent form, and although Kyler Murray is a good QB, they’re not playing well as a team.

Indianapolis is playing well, and it should cover the –6.5 spread.

Colts by 13

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4:00am Chargers vs. Dolphins @ Hard Rock Stadium

Betting Tip: Chargers -3.5 @ $1.90

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One of the hardest teams to follow every week are the Chargers, but at the –3.5 line, we can’t turn them down this week.

They have enough ability to make a deep playoff run, but they often produced a poor performance. We expect them to get back to their best against a Miami team playing without some of their best players.

Include Chargers –2.5 in your NFL picks this week.

Chargers by 7

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4:00am Patriots vs. Saints @ Caesars Superdome

Betting Tip: Patriots –3.5 @ $1.90

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We are going with another road team to cover the spread in Week 6. The Patriots are playing better than expected, and two of their three wins have come on the road.

We love the way they played against Buffalo last week to score an upset, and all things being equal, they should fancy themselves to beat teams like the Saints.

Covering a –3.5 line shouldn’t be too hard.

Patriots by 7

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4:00am Browns vs. Steelers @ Acrisure Stadium

Betting Tip: Steelers -6.5 @ $1.90

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It has been a bad start to the year for the Browns, who are trying to make moves at the quarterback position, but that’s nothing unusual.

The rivalry game against Pittsburgh won’t be easy for them, especially with the Steelers going under the radar at 3-1. They have played well enough to make a run for the division title, and with Baltimore giving up, they could have it in safe keeping.

Take the –6.5 line before it moves to –7.5 on game day.

Steeles by 7

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4:00am Cowboys vs. Panthers @ Bank of America Stadium

Betting Tip: Cowboys –3.5 @ $1.90

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The Cowboys are a team that could look great one day and shocking the next, but they have more talent on paper than Carolina.

Dallas has done well to post a 2-2-1 record, and the draw came in an amazing game against Green Bay, which should have given them confidence.

They play on the road, but if Dak Prescott is anywhere near his best, winning by four points won’t be hard.

Cowboys by 6

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4:00am Seahawks vs. Jaguars @ EverBank Stadium

Betting Tip: Jaguars @ $1.85

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The Jaguars did well to beat Kansas City last week, and if they play a similar brand of football, they should be too good for the Seahawks.

Sam Darnold is playing well for Seattle, but he came up with an untimely interception last week, which won’t do his confidence any favours.

Take the home side to continue its momentum.

Jaguars by 7

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4:00am Rams vs. Ravens @ M&T Bank Stadium

Betting Tip: Rams –7.5 @ $1.90

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The Ravens were Super Bowl favourites, but it has been a shocking start to the year, and now they’re hit with injuries.

Looking to take advantage are the Rams, who are firm favourites despite playing on the road, and they should get the job done easily.

Matthew Stafford could have a field day, so back the favourites.

Rams by 10

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7:05am Titans vs. Raiders @ Allegiant Stadium

Betting Tip: Titans +4.5 @ $1.90

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The Titans and Raiders are two bad teams, so we’re taking the value with the underdog on the road.

Tennessee will need to improve to win and cover the spread, but the Raiders have no confidence and taking them at $1.43 is a big risk.

It’s not the most popular game of the week, so tread carefully.

Titans by 3

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7:25am Bengals vs. Packers @ Lambeau Field

Betting Tip: Packers -14.5 @ $1.90

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The Packers are heavy favourites against the Bengals, who are having quarterback troubles, and they’re likely to continue.

Given the offence for Green Bay, it should have a field day on attack, and the Packers could put up a big score on the Bengals.

Take the –14.5 line before more money comes for them.

Packers by 17

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7:25am 49ers vs. Buccaneers @ Raymond James Stadium

Betting Tip: Buccaneers –2.5 @ $1.90

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We love what the Buccaneers have done this year, including an excellent win last week, and that form stacks up nicely against the 49ers.

Baker Mayfield is having another great year, and we’re surprised by the line. We rated them at around –6.5, so the –2.5 line is well worth including in NFL picks.

They are a good multi bet inclusion at the current line.

Buccaneers by 7

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11:20am Lions vs. Chiefs @ GEHA Field

Betting Tip: Lions @ $2.10

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The Lions are a strong Super Bowl chance, and they come into this game fresh. That bodes well against the Chiefs, who aren’t as good as they have been in previous years.

This is an ideal chance for the Lions to show that they’re one of the best in the NFL, and we thought they would be at shorter odds.

Take the current odds before late money comes.

Lions by 7

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Tuesday 14/10/25

10:15am Bills vs. Falcons @ Mercedes-Benz Stadium

Betting Tip: Bills -4.5 @ $1.90

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The Bills didn’t fire last week, but the Falcons are there to be beaten, and a big bounce back effort is expected.

Buffalo is still a strong Super Bowl contender, but it needs to produce the goods against easy teams like Atlanta. This is an ideal situation to score a win on the road.

The –4.5 line is generous from bookmakers.

Bills by 7

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11:15am Bears vs. Commanders @ Northwest Stadium

Betting Tip: Commanders –4.5 @ $1.90

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Not everything has gone right for the Commanders so far, but they are 2-0 at home, and that’s their best asset.

They could take advantage of the inconsistent Bears, who are always a risk to bet on, especially on the road. That’s why we’re picking the Commanders to win.

Take the –4.5 line and include them in NFL multis.

Commanders by 7

Editor In Chief

Daryl Curnow

After graduating from the University of Auckland (BA - English), Daryl was thrown into the world of sports and horse racing journalism.

Having worked as a racing journalist for two years, he decided to move into the online world of horse racing and sports writing. After years of honing his craft, Daryl became a professional punter in 2009 - with a focus on horse racing, NRL, AFL, NBA, Rugby, NFL, and US college sports.

Daryl's tips have been featured on various websites around the world before joining the GoBet team. When he's not working, Daryl tries to avoid making bogeys on the golf course.