Bills vs. Texans Predictions

We have Bills vs. Texans predictions for Week 12 of the NFL on Friday, November 21 at 12:15 PM.

The Bills look to strengthen their Super Bowl credentials with a win over Houston, who are barely holding on to a .500 record.

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Best Bet

Bills -5.5 @ $1.90

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The Bills haven’t been too consistent in 2025, but they were far too good for the Buccaneers last week, and that should be a good form guide.

They won 44-32 in a high-scoring affair, and we can’t see the Texans keeping up with them on offence. The Texans have struggled to score points, beating the Tennessee Titans just 16-13 last week, which wasn’t a good performance.

Josh Allen could have a field day at the quarterback position. He has 18 touchdowns for the season, and his best form could come over the next few weeks. Davis Mills is the Texans’ QB, and he will get overpowered by one of the best in the NFL.

Take the –5.5 line before money comes for the Bills on game day.

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Same Game Multi

Bills -5.5, Josh Allen Anytime Touchdown Scorer, James Cook Anytime Touchdown Scorer, Over 43.5 Points @ $7.75

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Allen was at his best last week with three touchdowns, and he could use play action to score another TD against the Texans. He’s a good running threat, and it’s an underrated part of his game. Punters get $1.96 for Allen to score, which is a good price.

James Cook is also a good chance to score. He got back to scoring form with a TD last week, and we’re backing him to score another.

Over 43.5 points is worth including in NFL picks this week. They combined for 43 points in their meeting last year, but there should be more points in this game.

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Best Value Bet

Bills 14+ @ $3.40

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We expect the Bills to be far too good for the Texans, and punters get $3.40 for the Bills to win by 14+ points.

There is a good chance of the Texans giving up easily in this game, and it could be a statement win for the Bills, who only need to live up to their potential.

Take the value odds for the visitors.

Editor In Chief

Daryl Curnow

After graduating from the University of Auckland (BA - English), Daryl was thrown into the world of sports and horse racing journalism.

Having worked as a racing journalist for two years, he decided to move into the online world of horse racing and sports writing. After years of honing his craft, Daryl became a professional punter in 2009 - with a focus on horse racing, NRL, AFL, NBA, Rugby, NFL, and US college sports.

Daryl's tips have been featured on various websites around the world before joining the GoBet team. When he's not working, Daryl tries to avoid making bogeys on the golf course.