49ers vs. Rams Predictions

We have 49ers vs. Rams predictions for Week 5 of the NFL on Friday, October 3 at 11:15 AM.

Week 5 gets started with the 49ers vs. Rams, where the Rams are –7.5 favourites at SoFi Stadium.

—

Best Bet

Rams -7.5 @ $1.90

Bet Now

We would have preferred the –6.5 line earlier this week, but the Rams should get the job done with ease against a hurting 49ers outfit. The 49ers have done well to post a 3-1 record, but they could start to struggle now.

Los Angeles bounced back from a loss to the Eagles with a tidy win over Indy, and a repeat of that effort should be enough to win and cover the spread at home.

We have been impressed by Matthew Stafford, who is a senior NFL player, and having that experience at the quarterback position helps. He has eight touchdowns and two interceptions, compared to 4-4 for 49ers QB Brock Purdy.

The Rams have a good team, and we’re backing them to win by 10 points.

—

Same Game Multi

Rams –7.5, Davante Adams Anytime Touchdown Scorer, Matthew Stafford Over 225 Passing Yards, Under 45.5 Points @ $12.75

Bet Now

Davante Adams has a touchdown in each of his last three games, so we’re confident of a big performance on Friday. He is a $2.20 chance to score for the Rams, which are much better odds than we expected.

We also like Stafford over 225 passing yards. He has 1,114 passing yards in 2025, and he likes to air the ball out, especially against a 49ers defence that is good against the run. He’s worth including in NFL SGM picks.

Under 45.5 points is worth including because the 49ers could struggle to score over 14 points. Their offence has been limited at times, and the final score could be around 27-14 to the Rams.

—

Best Value Bet

Davante Adams First Touchdown Scorer @ $7.25

Bet Now

Adams has been enjoying his time in Los Angeles, especially with Stafford throwing to him. That’s why we like them to connect on the first touchdown of the game.

He has been in fine touchdown-scoring form, catching three touchdown passes from his last three games. There is a lot to like about that form, so include Adams in your NFL prop picks.

Editor In Chief

Daryl Curnow

After graduating from the University of Auckland (BA - English), Daryl was thrown into the world of sports and horse racing journalism.

Having worked as a racing journalist for two years, he decided to move into the online world of horse racing and sports writing. After years of honing his craft, Daryl became a professional punter in 2009 - with a focus on horse racing, NRL, AFL, NBA, Rugby, NFL, and US college sports.

Daryl's tips have been featured on various websites around the world before joining the GoBet team. When he's not working, Daryl tries to avoid making bogeys on the golf course.