UEFA Champions League Playoff Round 2nd Leg Tips & Predictions

Following a frenetic first round of Champions League play-off fixtures, the same 16 teams shape up again this week, with spots in the knockout rounds at stake.

Goals were flying in across the continent last week and while every side will have a better idea of what they’re going up against, the intensity and rivalries will come to the fore.

For the likes of Inter Milan and Juventus, there are huge jobs to do, while tournament front runners PSG and Real Madrid will be eager to preserve their first leg leads.

Here are our Champions League tips for the play-off round, second leg fixtures in the 2025/26:

2025/26 UEFA Champions League Play Off Round, 2^nd Leg Predictions

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Atletico Madrid vs Club Brugge

Betting Tip: Atletico Madrid to win the match @ $1.40

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Atletico Madrid ($1.40)

Club Brugge ($8.00)

Draw ($6.80)

Aggregate Score: 3-3

An absolute classic was played out between these two sides in Belgium last week the rivalry continues between Atletico Madrid and Club Brugge. The Spanish side demonstrated their defensive frailties last week but should make amends here and with home support behind them, they look decent value to progress to the last 16 proper.

Atletico Madrid to win 3-1

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Bayer Leverkusen vs Olympiakos

Betting Tip: Bayer Leverkusen to win the match @ $1.80

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Bayer Leverkusen ($1.80)

Olympiakos ($4.80)

Draw ($4.20)

Aggregate Score: 2-0

It was the German giants Bayer Leverkusen who prevailed when these two sides met in Athens last week and Olympiakos will be desperate to engineer a response here. Leverkusen have warmed up into this Champions League campaign following a slow start and at home, they should have too much about them for the Greek champions.

Bayer Leverkusen to win 2-1

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Inter Milan vs Bodo/Glimt

Betting Tip: Inter Milan to win the match @ $1.25

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Inter Milan ($1.25)

Bodo/Glimt ($11.00)

Draw ($7.50)

Aggregate Score: 1-3

Perhaps the side with the biggest amount of work to do at this stage is Inter Milan, who were humbled on the road in Norway last week by Bodo/Glimt. Last year’s runners up Inter have huffed and puffed this season and have looked vulnerable. Beating Bodo/Glimt at the San Siro should be a guarantee for Inter but whether it is enough to progress remains to be seen.

Inter Milan to win 2-1

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Newcastle United vs FK Qarabag

Betting Tip: Newcastle United to win the match @ $1.17

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Newcastle United ($1.17)

FK Qarabag ($19.00)

Draw ($10.00)

Aggregate Score: 6-1

The team with the biggest statement result last week was Newcastle United and they will be looking to complete the job here against FK Qarabag. Toon were rampant in Azerbaijan, and they will be looking to rest a few key players here. This is a free hit for Qarabag but Newcastle should get it done, in this effectively dead rubber.

Newcastle United to win 2-0

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Atalanta vs Borussia Dortmund

Betting Tip: Atalanta to win the match @ $2.15

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Atalanta ($2.15)

Borussia Dortmund ($3.25)

Draw ($4.00)

Aggregate Score: 0-2

Following a relatively one-sided affair in Germany last week, Atalanta and Borussia Dortmund clash again in Bergamo, with the Italians having plenty to do. Dortmund hold a 2-0 lead and will play this one accordingly, which may suit Atalanta on the night, but the Germans are very much in pole position to progress.

Atalanta to win 2-1

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Juventus vs Galatasaray

Betting Tip: Juventus to win the match @ $1.50

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Juventus ($1.50)

Galatasaray ($5.80)

Draw ($5.00)

Aggregate Score: 2-5

Arguably the biggest result last week as Galatasaray’s 5-2 thumping of Juventus and the Turkish side have a serious lead to hang onto here. Tensions ran high between the sides in Istanbul, and this could carry over to Turin. Juventus should win this one at home but overturning a three goal deficit won’t be easy.

Juventus to win 3-1

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Real Madrid vs Benfica

Betting Tip: Real Madrid to win the match @ $1.50

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Real Madrid ($1.50)

Benfica ($7.00)

Draw ($5.50)

Aggregate Score: 1-0

Following shocking scenes in Lisbon last week, Real Madrid and Benfica meet for the next instalment of their burgeoning rivalry. With plenty of fall out still rumbling after last week, this should be a frantic on in Spain and while Benfica will be up for it, Real Madrid should put them to the sword here.

Real Madrid to win 3-0

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PSG vs Monaco

Betting Tip: PSG to win the match @ $1.30

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PSG ($1.30)

Monaco ($9.50)

Draw ($7.50)

Aggregate Score: 3-2

Holders PSG showed real resolve last week to come from two goals down to overcome Monaco and they will be eager to press home that advantage here in Paris. These two domestic rivals know each other very well and PSG should be able to navigate this one and reach the last 16 proper.

PSG to win 3-0

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2025/26 Champions League Play Off, 2^nd Leg multi bet

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We’re backing four results in the playoffs, as an accumulator with a betting stake of $50:

Atletico Madrid vs Club Brugge – Atletico Madrid
Juventus vs Galatasaray – Juventus
PSG vs Monaco – PSG
Real Madrid vs Benfica – Real Madrid

PSG, Juventus, Real Madrid & Atletico Madrid @ $6.80

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Sports Writer

Sam Hayes

Combining his sports coaching career with freelance journalism, Sam is a sports betting writer for various online publications.

He is looking to develop both his respective coaching and writing careers, whilst incorporating his other huge passion - travelling the world.

Sam currently lives and works in Milan, Italy and playing/following/writing about cricket, football (soccer), tennis, formula 1 and golf continue to take up much of his spare time.